The data were evaluated on a lesion and a patient basis. Any other foci of increased 131I uptake, except iodine uptake clearly located in the thyroid bed, were considered to be abnormal. Physiological uptake in the salivary glands, gastric mucosa, gut, nasal mucosa, urinary tract and liver were considered to be normal. Materials and methods A total of 53 SPECT-CT scans were performed in 41 patients with thyroid cancer after high-dose 131I therapy (2.944 to 7.526 GBq 131I) because of diagnostic uncertainty on ptWBS. Purpose The purpose of this prospective study was to determine the diagnostic impact and influence on patient treatment of posttherapeutic 131I SPECT-CT when the findings on planar posttherapeutic whole-body scintigraphy (ptWBS) were inconclusive.
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